Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance

BACKGROUND: Insulin-degrading enzyme (IDE) is widely recognized as the principal protease responsible for the clearance and inactivation of insulin, but its role in glycemic control in vivo is poorly understood. We present here the first longitudinal characterization, to our knowledge, of glucose re...

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Detalles Bibliográficos
Autores principales: Abdul-Hay, Samer O., Kang, Dongcheul, McBride, Melinda, Li, Lilin, Zhao, Ji, Leissring, Malcolm A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111440/
https://www.ncbi.nlm.nih.gov/pubmed/21695259
http://dx.doi.org/10.1371/journal.pone.0020818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111440/
https://www.ncbi.nlm.nih.gov/pubmed/21695259
http://dx.doi.org/10.1371/journal.pone.0020818

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