p53 Gene Repair with Zinc Finger Nucleases Optimised by Yeast 1-Hybrid and Validated by Solexa Sequencing

The tumor suppressor gene p53 is mutated or deleted in over 50% of human tumors. As functional p53 plays a pivotal role in protecting against cancer development, several strategies for restoring wild-type (wt) p53 function have been investigated. In this study, we applied an approach using gene repa...

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Detalles Bibliográficos
Autores principales: Herrmann, Frank, Garriga-Canut, Mireia, Baumstark, Rebecca, Fajardo-Sanchez, Emmanuel, Cotterell, James, Minoche, André, Himmelbauer, Heinz, Isalan, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111460/
https://www.ncbi.nlm.nih.gov/pubmed/21695267
http://dx.doi.org/10.1371/journal.pone.0020913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111460/
https://www.ncbi.nlm.nih.gov/pubmed/21695267
http://dx.doi.org/10.1371/journal.pone.0020913

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