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p53 Gene Repair with Zinc Finger Nucleases Optimised by Yeast 1-Hybrid and Validated by Solexa Sequencing
The tumor suppressor gene p53 is mutated or deleted in over 50% of human tumors. As functional p53 plays a pivotal role in protecting against cancer development, several strategies for restoring wild-type (wt) p53 function have been investigated. In this study, we applied an approach using gene repa...
Autores principales: | Herrmann, Frank, Garriga-Canut, Mireia, Baumstark, Rebecca, Fajardo-Sanchez, Emmanuel, Cotterell, James, Minoche, André, Himmelbauer, Heinz, Isalan, Mark |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111460/ https://www.ncbi.nlm.nih.gov/pubmed/21695267 http://dx.doi.org/10.1371/journal.pone.0020913 |
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