Testing the Ortholog Conjecture with Comparative Functional Genomic Data from Mammals

A common assumption in comparative genomics is that orthologous genes share greater functional similarity than do paralogous genes (the “ortholog conjecture”). Many methods used to computationally predict protein function are based on this assumption, even though it is largely untested. Here we pres...

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Detalles Bibliográficos
Autores principales: Nehrt, Nathan L., Clark, Wyatt T., Radivojac, Predrag, Hahn, Matthew W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111532/
https://www.ncbi.nlm.nih.gov/pubmed/21695233
http://dx.doi.org/10.1371/journal.pcbi.1002073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111532/
https://www.ncbi.nlm.nih.gov/pubmed/21695233
http://dx.doi.org/10.1371/journal.pcbi.1002073

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