A cancer-derived mutation in the PSTAIRE helix of cyclin-dependent kinase 2 alters the stability of cyclin binding

Cyclin-dependent kinase 2 (cdk2) is a central regulator of the mammalian cell cycle. Here we describe the properties of a mutant form of cdk2 identified during large-scale sequencing of protein kinases from cancerous tissue. The mutation substituted a leucine for a proline in the PSTAIRE helix, the...

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Detalles Bibliográficos
Autores principales: Child, Emma S., Hendrychová, Tereza, McCague, Karen, Futreal, Andy, Otyepka, Michal, Mann, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111755/
https://www.ncbi.nlm.nih.gov/pubmed/20399812
http://dx.doi.org/10.1016/j.bbamcr.2010.04.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111755/
https://www.ncbi.nlm.nih.gov/pubmed/20399812
http://dx.doi.org/10.1016/j.bbamcr.2010.04.004

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