Clarifying mammalian RISC assembly in vitro

BACKGROUND: Argonaute, the core component of the RNA induced silencing complex (RISC), binds to mature miRNAs and regulates gene expression at transcriptional or post-transcriptional level. We recently reported that Argonaute 2 (Ago2) also assembles into complexes with miRNA precursors (pre-miRNAs)....

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Detalles Bibliográficos
Autores principales: Tan, Grace S, Garchow, Barry G, Liu, Xuhang, Metzler, David, Kiriakidou, Marianthi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112105/
https://www.ncbi.nlm.nih.gov/pubmed/21529364
http://dx.doi.org/10.1186/1471-2199-12-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112105/
https://www.ncbi.nlm.nih.gov/pubmed/21529364
http://dx.doi.org/10.1186/1471-2199-12-19

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