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HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop

BACKGROUND: Stat3 is a cytokine- and growth factor-inducible transcription factor that regulates cell motility, migration, and invasion under normal and pathological situations, making it a promising target for cancer therapeutics. The hepatocyte growth factor (HGF)/c-met receptor tyrosine kinase si...

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Detalles Bibliográficos
Autores principales: Syed, Zanobia A, Yin, Weihong, Hughes, Kendall, Gill, Jennifer N, Shi, Runhua, Clifford, John L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112164/
https://www.ncbi.nlm.nih.gov/pubmed/21595927
http://dx.doi.org/10.1186/1471-2407-11-180