Hepatocyte-Targeted Expression by Integrase-Defective Lentiviral Vectors Induces Antigen-Specific Tolerance in Mice with Low Genotoxic Risk

Lentiviral vectors are attractive tools for liver-directed gene therapy because of their capacity for stable gene expression and the lack of preexisting immunity in most human subjects. However, the use of integrating vectors may raise some concerns about the potential risk of insertional mutagenesi...

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Detalles Bibliográficos
Autores principales: Mátrai, Janka, Cantore, Alessio, Bartholomae, Cynthia C, Annoni, Andrea, Wang, Wei, Acosta-Sanchez, Abel, Samara-Kuko, Ermira, De Waele, Liesbeth, Ma, Ling, Genovese, Pietro, Damo, Martina, Arens, Anne, Goudy, Kevin, Nichols, Timothy C, von Kalle, Christof, Chuah, Marinee K L, Roncarolo, Maria Grazia, Schmidt, Manfred, VandenDriessche, Thierry, Naldini, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2011
Materias:
Liver Biology/Pathobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112259/
https://www.ncbi.nlm.nih.gov/pubmed/21520180
http://dx.doi.org/10.1002/hep.24230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112259/
https://www.ncbi.nlm.nih.gov/pubmed/21520180
http://dx.doi.org/10.1002/hep.24230

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