Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies

Aggresomes and related inclusion bodies appear to serve as storage depots for misfolded and aggregated proteins within cells, which can potentially be degraded by the autophagy pathway. A homogenous fluorescence-based assay was devised to detect aggregated proteins inside aggresomes and inclusion bo...

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Detalles Bibliográficos
Autores principales: Shen, Dee, Coleman, Jack, Chan, Eric, Nicholson, Thomas P., Dai, Lijun, Sheppard, Paul W., Patton, Wayne F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Humana Press Inc 2010
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112480/
https://www.ncbi.nlm.nih.gov/pubmed/21132543
http://dx.doi.org/10.1007/s12013-010-9138-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112480/
https://www.ncbi.nlm.nih.gov/pubmed/21132543
http://dx.doi.org/10.1007/s12013-010-9138-4

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