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Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior
BACKGROUND: Interleukin (IL)-6 is produced in the brain during peripheral infection and plays an important but poorly understood role in sickness behavior. Therefore, this study investigated the capacity of soluble gp130 (sgp130), a natural inhibitor of the IL-6 trans-signaling pathway to regulate I...
Autores principales: | Burton, Michael D, Sparkman, Nathan L, Johnson, Rodney W |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113341/ https://www.ncbi.nlm.nih.gov/pubmed/21595956 http://dx.doi.org/10.1186/1742-2094-8-54 |
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