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The conformation of microRNA seed regions in native microRNPs is prearranged for presentation to mRNA targets
MicroRNAs control gene expression by post-transcriptional down-regulation of their target mRNAs. Complementarity between the seed region (nucleotides 2–8) of a microRNA and the 3′-UTR of its target mRNA is the key determinant in recognition. However, the structural basis of the ability of the seed r...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113585/ https://www.ncbi.nlm.nih.gov/pubmed/21335607 http://dx.doi.org/10.1093/nar/gkr077 |