Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes

Single-stranded antisense oligonucleotides (SSOs) are used to modulate the expression of genes in animal models and are being investigated as potential therapeutics. To better understand why synthetic SSOs accumulate in the same intracellular location as the target RNA, we have isolated a novel mous...

Descripción completa

Detalles Bibliográficos
Autores principales: Koller, Erich, Vincent, Thomas M., Chappell, Alfred, De, Soma, Manoharan, Muthiah, Bennett, C. Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113586/
https://www.ncbi.nlm.nih.gov/pubmed/21345934
http://dx.doi.org/10.1093/nar/gkr089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113586/
https://www.ncbi.nlm.nih.gov/pubmed/21345934
http://dx.doi.org/10.1093/nar/gkr089

Ejemplares similares