A method to sequence and quantify DNA integration for monitoring outcome in gene therapy

Human genetic diseases have been successfully corrected by integration of functional copies of the defective genes into human cells, but in some cases integration of therapeutic vectors has activated proto-oncogenes and contributed to leukemia. For this reason, extensive efforts have focused on anal...

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Detalles Bibliográficos
Autores principales: Brady, Troy, Roth, Shoshannah L., Malani, Nirav, Wang, Gary P., Berry, Charles C., Leboulch, Philippe, Hacein-Bey-Abina, Salima, Cavazzana-Calvo, Marina, Papapetrou, Eirini P., Sadelain, Michel, Savilahti, Harri, Bushman, Frederic D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113588/
https://www.ncbi.nlm.nih.gov/pubmed/21415009
http://dx.doi.org/10.1093/nar/gkr140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113588/
https://www.ncbi.nlm.nih.gov/pubmed/21415009
http://dx.doi.org/10.1093/nar/gkr140

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