The Interplay between Protein L-Isoaspartyl Methyltransferase Activity and Insulin-Like Signaling to Extend Lifespan in Caenorhabditis elegans

The protein L-isoaspartyl-O-methyltransferase functions to initiate the repair of isomerized aspartyl and asparaginyl residues that spontaneously accumulate with age in a variety of organisms. Caenorhabditis elegans nematodes lacking the pcm-1 gene encoding this enzyme display a normal lifespan and...

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Detalles Bibliográficos
Autores principales: Khare, Shilpi, Linster, Carole L., Clarke, Steven G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113807/
https://www.ncbi.nlm.nih.gov/pubmed/21695191
http://dx.doi.org/10.1371/journal.pone.0020850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113807/
https://www.ncbi.nlm.nih.gov/pubmed/21695191
http://dx.doi.org/10.1371/journal.pone.0020850

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