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Conformation-regulated mechanosensory control via titin domains in cardiac muscle

The giant filamentous protein titin is ideally positioned in the muscle sarcomere to sense mechanical stimuli and transform them into biochemical signals, such as those triggering cardiac hypertrophy. In this review, we ponder the evidence for signaling hotspots along the titin filament involved in...

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Detalles Bibliográficos
Autores principales: Voelkel, Tobias, Linke, Wolfgang A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114084/
https://www.ncbi.nlm.nih.gov/pubmed/21347754
http://dx.doi.org/10.1007/s00424-011-0938-1