Cargando…

Conformation-regulated mechanosensory control via titin domains in cardiac muscle

The giant filamentous protein titin is ideally positioned in the muscle sarcomere to sense mechanical stimuli and transform them into biochemical signals, such as those triggering cardiac hypertrophy. In this review, we ponder the evidence for signaling hotspots along the titin filament involved in...

Descripción completa

Detalles Bibliográficos
Autores principales: Voelkel, Tobias, Linke, Wolfgang A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114084/
https://www.ncbi.nlm.nih.gov/pubmed/21347754
http://dx.doi.org/10.1007/s00424-011-0938-1
_version_ 1782206027165335552
author Voelkel, Tobias
Linke, Wolfgang A.
author_facet Voelkel, Tobias
Linke, Wolfgang A.
author_sort Voelkel, Tobias
collection PubMed
description The giant filamentous protein titin is ideally positioned in the muscle sarcomere to sense mechanical stimuli and transform them into biochemical signals, such as those triggering cardiac hypertrophy. In this review, we ponder the evidence for signaling hotspots along the titin filament involved in mechanosensory control mechanisms. On the way, we distinguish between stress and strain as triggers of mechanical signaling events at the cardiac sarcomere. Whereas the Z-disk and M-band regions of titin may be prominently involved in sensing mechanical stress, signaling hotspots within the elastic I-band titin segment may respond primarily to mechanical strain. Common to both stress and strain sensor elements is their regulation by conformational changes in protein domains.
format Online
Article
Text
id pubmed-3114084
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Springer-Verlag
record_format MEDLINE/PubMed
spelling pubmed-31140842011-07-14 Conformation-regulated mechanosensory control via titin domains in cardiac muscle Voelkel, Tobias Linke, Wolfgang A. Pflugers Arch Invited Review The giant filamentous protein titin is ideally positioned in the muscle sarcomere to sense mechanical stimuli and transform them into biochemical signals, such as those triggering cardiac hypertrophy. In this review, we ponder the evidence for signaling hotspots along the titin filament involved in mechanosensory control mechanisms. On the way, we distinguish between stress and strain as triggers of mechanical signaling events at the cardiac sarcomere. Whereas the Z-disk and M-band regions of titin may be prominently involved in sensing mechanical stress, signaling hotspots within the elastic I-band titin segment may respond primarily to mechanical strain. Common to both stress and strain sensor elements is their regulation by conformational changes in protein domains. Springer-Verlag 2011-02-25 2011 /pmc/articles/PMC3114084/ /pubmed/21347754 http://dx.doi.org/10.1007/s00424-011-0938-1 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Invited Review
Voelkel, Tobias
Linke, Wolfgang A.
Conformation-regulated mechanosensory control via titin domains in cardiac muscle
title Conformation-regulated mechanosensory control via titin domains in cardiac muscle
title_full Conformation-regulated mechanosensory control via titin domains in cardiac muscle
title_fullStr Conformation-regulated mechanosensory control via titin domains in cardiac muscle
title_full_unstemmed Conformation-regulated mechanosensory control via titin domains in cardiac muscle
title_short Conformation-regulated mechanosensory control via titin domains in cardiac muscle
title_sort conformation-regulated mechanosensory control via titin domains in cardiac muscle
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114084/
https://www.ncbi.nlm.nih.gov/pubmed/21347754
http://dx.doi.org/10.1007/s00424-011-0938-1
work_keys_str_mv AT voelkeltobias conformationregulatedmechanosensorycontrolviatitindomainsincardiacmuscle
AT linkewolfganga conformationregulatedmechanosensorycontrolviatitindomainsincardiacmuscle