p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor

The DNp73 proteins act as trans-repressors of p53 and p73-dependent transcription and exert both anti-apoptotic activity and pro-proliferative activity. DNp73s are frequently up-regulated in a variety of human cancers, including human hepatocellular carcinomas (HCCs). Increased levels of DNp73 prote...

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Detalles Bibliográficos
Autores principales: Testoni, B, Schinzari, V, Guerrieri, F, Gerbal-Chaloin, S, Blandino, G, Levrero, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114186/
https://www.ncbi.nlm.nih.gov/pubmed/21399658
http://dx.doi.org/10.1038/onc.2010.635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114186/
https://www.ncbi.nlm.nih.gov/pubmed/21399658
http://dx.doi.org/10.1038/onc.2010.635

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