Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance

OBJECTIVE: Metreleptin has been efficacious in improving metabolic control in patients with lipodystrophy, but its efficacy has not been tested in obese patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: We studied the role of leptin in regulating the endocrine adaptation to long-term calor...

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Detalles Bibliográficos
Autores principales: Moon, Hyun-Seuk, Matarese, Giuseppe, Brennan, Aoife M., Chamberland, John P., Liu, Xiaowen, Fiorenza, Christina G., Mylvaganam, Geetha H., Abanni, Luisa, Carbone, Fortunata, Williams, Catherine J., De Paoli, Alex M., Schneider, Benjamin E., Mantzoros, Christos S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Perspectives in Diabetes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114380/
https://www.ncbi.nlm.nih.gov/pubmed/21617185
http://dx.doi.org/10.2337/db10-1791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114380/
https://www.ncbi.nlm.nih.gov/pubmed/21617185
http://dx.doi.org/10.2337/db10-1791

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