Cargando…

Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance

OBJECTIVE: Metreleptin has been efficacious in improving metabolic control in patients with lipodystrophy, but its efficacy has not been tested in obese patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: We studied the role of leptin in regulating the endocrine adaptation to long-term calor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moon, Hyun-Seuk, Matarese, Giuseppe, Brennan, Aoife M., Chamberland, John P., Liu, Xiaowen, Fiorenza, Christina G., Mylvaganam, Geetha H., Abanni, Luisa, Carbone, Fortunata, Williams, Catherine J., De Paoli, Alex M., Schneider, Benjamin E., Mantzoros, Christos S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Perspectives in Diabetes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114380/ https://www.ncbi.nlm.nih.gov/pubmed/21617185 http://dx.doi.org/10.2337/db10-1791

Ejemplares similares

Leptin and Amylin Act in an Additive Manner to Activate Overlapping Signaling Pathways in Peripheral Tissues: In vitro and ex vivo studies in humans
por: Moon, Hyun-Seuk, et al.
Publicado: (2011)

SAT089 Natural History Of Generalized Lipodystrophy Following Early Vs. Late Metreleptin Treatment
por: Brush, Maiah, et al.
Publicado: (2023)

Fibroblast Growth Factor 21 Levels in Young Healthy Females Display Day and Night Variations and Are Increased in Response to Short-Term Energy Deprivation Through a Leptin-Independent Pathway
por: Foo, Joo-Pin, et al.
Publicado: (2013)

Omentin-1 levels are reduced by pharmacologic doses of leptin, but remain unaffected by energy deprivation and display no day-night variation
por: Hamnvik, Ole-Petter Riksfjord, et al.
Publicado: (2014)

First Account of Psychological Changes Perceived by a Female with Congenital Leptin Deficiency upon Treatment with Metreleptin
por: Hebebrand, Johannes, et al.
Publicado: (2022)

Metreleptin therapy in LMNA-linked lipodystrophies
por: Vatier, Camille, et al.
Publicado: (2015)

Leptin in Relation to the Lipodystrophy-Associated Metabolic Syndrome
por: Mantzoros, Christos S.
Publicado: (2012)

Immune Recognition of β-Cells: Neoepitopes as Key Players in the Loss of Tolerance
por: James, Eddie A., et al.
Publicado: (2018)

OR33-02 The Treatment of Partial Lipodystrophy in the Setting of Neutralizing Antibody Against Metreleptin with Leptin Receptor Agonist REGN4461
por: Akinci, Baris, et al.
Publicado: (2020)

Leptin and Its Emerging Role in Children and Adolescents
por: Kelesidis, Iosif, et al.
Publicado: (2006)

Metreleptin Treatment in Three Patients with Generalized Lipodystrophy
por: Musso, Carla, et al.
Publicado: (2017)

The Metabolic Progression to Type 1 Diabetes as Indicated by Serial Oral Glucose Tolerance Testing in the Diabetes Prevention Trial–Type 1
por: Sosenko, Jay M., et al.
Publicado: (2012)

New advances in the treatment of generalized lipodystrophy: role of metreleptin
por: Rodriguez, Alexander J, et al.
Publicado: (2015)

Suggestive Evidence for an Antidepressant Effect of Metreleptin Treatment in Patients with Lipodystrophy
por: Vieira, Diana Branco, et al.
Publicado: (2022)

Leptin as a Modulator of Neuroendocrine Function in Humans
por: Khan, Sami M., et al.
Publicado: (2012)

Adherence with metreleptin therapy and health self-perception in patients with lipodystrophic syndromes
por: Vatier, Camille, et al.
Publicado: (2019)

Risk factors for diabetic foot ulcers in metreleptin naïve patients with lipodystrophy
por: Saydam, O, et al.
Publicado: (2021)

The Metreleptin Effectiveness and Safety Registry (MEASuRE): concept, design and challenges
por: Haymond, Morey W, et al.
Publicado: (2023)

Hypothalamic Leptin Resistance: From BBB to BBSome
por: López, Miguel
Publicado: (2016)

SUN-607 Iron Parameters in Patients with Partial Lipodystrophy and Impact of Metreleptin Therapy
por: Boutros, Sabine, et al.
Publicado: (2020)

Association of Leptin With Obesity and Insulin Resistance
por: Kumar, Ratan, et al.
Publicado: (2020)

Leptin and Soluble Leptin Receptor Levels in Plasma and Risk of Type 2 Diabetes in U.S. Women: A Prospective Study
por: Sun, Qi, et al.
Publicado: (2010)

The “Perfect Storm” for Type 1 Diabetes: The Complex Interplay Between Intestinal Microbiota, Gut Permeability, and Mucosal Immunity
por: Vaarala, Outi, et al.
Publicado: (2008)

Viral Trigger for Type 1 Diabetes: Pros and Cons
por: Filippi, Christophe M., et al.
Publicado: (2008)

Primer: Immunity and Autoimmunity
por: Pietropaolo, Massimo, et al.
Publicado: (2008)

β-Cell Mass and Type 1 Diabetes: Going, Going, Gone?
por: Akirav, Eitan, et al.
Publicado: (2008)

Learning From Molecular Genetics: Novel Insights Arising From the Definition of Genes for Monogenic and Type 2 Diabetes
por: McCarthy, Mark I., et al.
Publicado: (2008)

Islets in Type 2 Diabetes: In Honor of Dr. Robert C. Turner
por: Bonner-Weir, Susan, et al.
Publicado: (2008)

Human Obesity: A Heritable Neurobehavioral Disorder That Is Highly Sensitive to Environmental Conditions
por: O'Rahilly, Stephen, et al.
Publicado: (2008)

Protein Kinase C Function in Muscle, Liver, and β-Cells and Its Therapeutic Implications for Type 2 Diabetes
por: Schmitz-Peiffer, Carsten, et al.
Publicado: (2008)

Immunomodulation by Mesenchymal Stem Cells : A Potential Therapeutic Strategy for Type 1 Diabetes
por: Abdi, Reza, et al.
Publicado: (2008)

Neurophysiological Pathways to Obesity: Below Awareness and Beyond Individual Control
por: Cohen, Deborah A.
Publicado: (2008)

The Barrier of Hypoglycemia in Diabetes
por: Cryer, Philip E.
Publicado: (2008)

Minimizing Hypoglycemia While Maintaining Glycemic Control in Diabetes
por: Heller, Simon R.
Publicado: (2008)

Maternal Environment and the Transgenerational Cycle of Obesity and Diabetes
por: Dabelea, Dana, et al.
Publicado: (2011)

Diabetes Complications: The MicroRNA Perspective
por: Kantharidis, Phillip, et al.
Publicado: (2011)

The Paradox of Progress: Environmental Disruption of Metabolism and the Diabetes Epidemic
por: Neel, Brian A., et al.
Publicado: (2011)

MicroRNAs in β-Cell Biology, Insulin Resistance, Diabetes and Its Complications
por: Fernandez-Valverde, Selene L., et al.
Publicado: (2011)

Historical Perspective: Beginnings of the β-Cell: Current Perspectives in β-Cell Development
por: Seymour, Philip A., et al.
Publicado: (2011)

The Complex Mechanism of Glutamate Dehydrogenase in Insulin Secretion
por: Fahien, Leonard A., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_lg68c0712pnu4vc77dknsh7200