In Vivo Conditional Pax4 Overexpression in Mature Islet β-Cells Prevents Stress-Induced Hyperglycemia in Mice

OBJECTIVE: To establish the role of the transcription factor Pax4 in pancreatic islet expansion and survival in response to physiological stress and its impact on glucose metabolism, we generated transgenic mice conditionally and selectively overexpressing Pax4 or a diabetes-linked mutant variant (P...

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Detalles Bibliográficos
Autores principales: He, Kai Hui Hu, Lorenzo, Petra I., Brun, Thierry, Jimenez Moreno, Carmen M., Aeberhard, Deborah, Ortega, Jorge Vallejo, Cornu, Marion, Thorel, Fabrizio, Gjinovci, Asllan, Thorens, Bernard, Herrera, Pedro L., Meda, Paolo, Wollheim, Claes B., Gauthier, Benoit R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114382/
https://www.ncbi.nlm.nih.gov/pubmed/21521872
http://dx.doi.org/10.2337/db10-1102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114382/
https://www.ncbi.nlm.nih.gov/pubmed/21521872
http://dx.doi.org/10.2337/db10-1102

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