HLA-A2–Matched Peripheral Blood Mononuclear Cells From Type 1 Diabetic Patients, but Not Nondiabetic Donors, Transfer Insulitis to NOD-scid/γc(null)/HLA-A2 Transgenic Mice Concurrent With the Expansion of Islet-Specific CD8(+) T cells

OBJECTIVE: Type 1 diabetes is an autoimmune disease characterized by the destruction of insulin-producing β-cells. NOD mice provide a useful tool for understanding disease pathogenesis and progression. Although much has been learned from studies with NOD mice, increased understanding of human type 1...

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Detalles Bibliográficos
Autores principales: Whitfield-Larry, Fatima, Young, Ellen F., Talmage, Garrick, Fudge, Elizabeth, Azam, Anita, Patel, Shipra, Largay, Joseph, Byrd, Warren, Buse, John, Calikoglu, Ali S., Shultz, Leonard D., Frelinger, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114397/
https://www.ncbi.nlm.nih.gov/pubmed/21521873
http://dx.doi.org/10.2337/db10-1287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114397/
https://www.ncbi.nlm.nih.gov/pubmed/21521873
http://dx.doi.org/10.2337/db10-1287

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