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Decreased Cerebrovascular Brain-Derived Neurotrophic Factor–Mediated Neuroprotection in the Diabetic Brain

OBJECTIVE: Diabetes is an independent risk factor for stroke. However, the underlying mechanism of how diabetes confers that this risk is not fully understood. We hypothesize that secretion of neurotrophic factors by the cerebral endothelium, such as brain-derived neurotrophic factor (BDNF), is supp...

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Detalles Bibliográficos
Autores principales: Navaratna, Deepti, Guo, Shu-zhen, Hayakawa, Kazhuhide, Wang, Xiaoying, Gerhardinger, Chiara, Lo, Eng H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114398/
https://www.ncbi.nlm.nih.gov/pubmed/21562076
http://dx.doi.org/10.2337/db10-1371