TP53 Status and Response to Treatment in Breast Cancers

The p53 wild-type protein plays an important role in cells as is shown by its fine regulation at different levels. Since its discovery, numerous mutations have been described. In breast cancers, p53 is mutated in almost 30% of cases, with a higher frequency in some tumor subtypes. TP53 mutation is r...

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Detalles Bibliográficos
Autores principales: Varna, Mariana, Bousquet, Guilhem, Plassa, Louis-François, Bertheau, Philippe, Janin, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114547/
https://www.ncbi.nlm.nih.gov/pubmed/21760703
http://dx.doi.org/10.1155/2011/284584
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author Varna, Mariana
Bousquet, Guilhem
Plassa, Louis-François
Bertheau, Philippe
Janin, Anne
author_facet Varna, Mariana
Bousquet, Guilhem
Plassa, Louis-François
Bertheau, Philippe
Janin, Anne
author_sort Varna, Mariana
collection PubMed
description The p53 wild-type protein plays an important role in cells as is shown by its fine regulation at different levels. Since its discovery, numerous mutations have been described. In breast cancers, p53 is mutated in almost 30% of cases, with a higher frequency in some tumor subtypes. TP53 mutation is reported to be a factor for good prognosis in some studies, while in others it is a factor for poor prognosis. The explanation for these different results could be linked to the fact that the studies were performed on different tumor types and with different therapy regimens.
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spelling pubmed-31145472011-07-14 TP53 Status and Response to Treatment in Breast Cancers Varna, Mariana Bousquet, Guilhem Plassa, Louis-François Bertheau, Philippe Janin, Anne J Biomed Biotechnol Review Article The p53 wild-type protein plays an important role in cells as is shown by its fine regulation at different levels. Since its discovery, numerous mutations have been described. In breast cancers, p53 is mutated in almost 30% of cases, with a higher frequency in some tumor subtypes. TP53 mutation is reported to be a factor for good prognosis in some studies, while in others it is a factor for poor prognosis. The explanation for these different results could be linked to the fact that the studies were performed on different tumor types and with different therapy regimens. Hindawi Publishing Corporation 2011 2011-05-09 /pmc/articles/PMC3114547/ /pubmed/21760703 http://dx.doi.org/10.1155/2011/284584 Text en Copyright © 2011 Mariana Varna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Varna, Mariana
Bousquet, Guilhem
Plassa, Louis-François
Bertheau, Philippe
Janin, Anne
TP53 Status and Response to Treatment in Breast Cancers
title TP53 Status and Response to Treatment in Breast Cancers
title_full TP53 Status and Response to Treatment in Breast Cancers
title_fullStr TP53 Status and Response to Treatment in Breast Cancers
title_full_unstemmed TP53 Status and Response to Treatment in Breast Cancers
title_short TP53 Status and Response to Treatment in Breast Cancers
title_sort tp53 status and response to treatment in breast cancers
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114547/
https://www.ncbi.nlm.nih.gov/pubmed/21760703
http://dx.doi.org/10.1155/2011/284584
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