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Towards a Pharmacophore for Amyloid

Diagnosing and treating Alzheimer's and other diseases associated with amyloid fibers remains a great challenge despite intensive research. To aid in this effort, we present atomic structures of fiber-forming segments of proteins involved in Alzheimer's disease in complex with small molecu...

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Detalles Bibliográficos
Autores principales: Landau, Meytal, Sawaya, Michael R., Faull, Kym F., Laganowsky, Arthur, Jiang, Lin, Sievers, Stuart A., Liu, Jie, Barrio, Jorge R., Eisenberg, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114762/
https://www.ncbi.nlm.nih.gov/pubmed/21695112
http://dx.doi.org/10.1371/journal.pbio.1001080