Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease

BACKGROUND: Mechanisms whereby gene–environment interactions mediate chronic, progressive neurodegenerative processes in Parkinson’s disease (PD)—the second most common neurodegenerative disease—remain elusive. OBJECTIVE: We created a two-hit [neuroinflammation and mutant α-synuclein (α-syn) overexp...

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Detalles Bibliográficos
Autores principales: Gao, Hui-Ming, Zhang, Feng, Zhou, Hui, Kam, Wayneho, Wilson, Belinda, Hong, Jau-Shyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114815/
https://www.ncbi.nlm.nih.gov/pubmed/21245015
http://dx.doi.org/10.1289/ehp.1003013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114815/
https://www.ncbi.nlm.nih.gov/pubmed/21245015
http://dx.doi.org/10.1289/ehp.1003013

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