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Osteopenia Due to Enhanced Cathepsin K Release by BK Channel Ablation in Osteoclasts
BACKGROUND: The process of bone resorption by osteoclasts is regulated by Cathepsin K, the lysosomal collagenase responsible for the degradation of the organic bone matrix during bone remodeling. Recently, Cathepsin K was regarded as a potential target for therapeutic intervention of osteoporosis. H...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114853/ https://www.ncbi.nlm.nih.gov/pubmed/21695131 http://dx.doi.org/10.1371/journal.pone.0021168 |