Analyzing Airway Inflammation with Chemical Biology: Dissection of Acidic Mammalian Chitinase Function with a Selective Drug-like Inhibitor

Acidic mammalian chitinase (AMCase) is produced in the lung during allergic inflammation and asthma, and inhibition of enzymatic activity has been considered as a therapeutic strategy. However, most chitinase inhibitors are nonselective, additionally inhibiting chitotriosidase activity. Here, we des...

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Detalles Bibliográficos
Autores principales: Sutherland, Tara E., Andersen, Ole A., Betou, Marie, Eggleston, Ian M., Maizels, Rick M., van Aalten, Daan, Allen, Judith E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115046/
https://www.ncbi.nlm.nih.gov/pubmed/21609838
http://dx.doi.org/10.1016/j.chembiol.2011.02.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115046/
https://www.ncbi.nlm.nih.gov/pubmed/21609838
http://dx.doi.org/10.1016/j.chembiol.2011.02.017

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