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Adaptive evolution of the vertebrate skeletal muscle sodium channel

Tetrodotoxin (TTX) is a highly potent neurotoxin that blocks the action potential by selectively binding to voltage-gated sodium channels (Na(v)). The skeletal muscle Na(v) (Na(v)1.4) channels in most pufferfish species and certain North American garter snakes are resistant to TTX, whereas in most m...

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Detalles Bibliográficos
Autores principales: Lu, Jian, Zheng, Jianzhou, Xu, Qinggang, Chen, Keping, Zhang, Chiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115330/
https://www.ncbi.nlm.nih.gov/pubmed/21734837
http://dx.doi.org/10.1590/S1415-47572011000200026