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Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation
High expression of the protein kinase Bub1 has been observed in a variety of human tumors and often correlates with poor clinical prognosis, but its molecular and cellular consequences and role in tumorigenesis are unknown. Here, we demonstrate that overexpression of Bub1 in mice leads to near-diplo...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115799/ https://www.ncbi.nlm.nih.gov/pubmed/21646403 http://dx.doi.org/10.1083/jcb.201012035 |