A Novel Synthetic Smoothened Antagonist Transiently Inhibits Pancreatic Adenocarcinoma Xenografts in a Mouse Model

BACKGROUND: Hedgehog (Hh) signaling is over-activated in several solid tumors where it plays a central role in cell growth, stroma recruitment and tumor progression. In the Hh signaling pathway, the Smoothened (SMO) receptor comprises a primary drug target with experimental small molecule SMO antago...

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Detalles Bibliográficos
Autores principales: Strand, Martin F., Wilson, Steven R., Dembinski, Jennifer L., Holsworth, Daniel D., Khvat, Alexander, Okun, Ilya, Petersen, Dirk, Krauss, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115942/
https://www.ncbi.nlm.nih.gov/pubmed/21698280
http://dx.doi.org/10.1371/journal.pone.0019904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115942/
https://www.ncbi.nlm.nih.gov/pubmed/21698280
http://dx.doi.org/10.1371/journal.pone.0019904

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