Influenza A Virus Nucleoprotein Exploits Hsp40 to Inhibit PKR Activation

BACKGROUND: Double-stranded RNA dependent protein kinase (PKR) is a key regulator of the anti-viral innate immune response in mammalian cells. PKR activity is regulated by a 58 kilo Dalton cellular inhibitor (P58(IPK)), which is present in inactive state as a complex with Hsp40 under normal conditio...

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Detalles Bibliográficos
Autores principales: Sharma, Kulbhushan, Tripathi, Shashank, Ranjan, Priya, Kumar, Purnima, Garten, Rebecca, Deyde, Varough, Katz, Jacqueline M., Cox, Nancy J., Lal, Renu B., Sambhara, Suryaprakash, Lal, Sunil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115951/
https://www.ncbi.nlm.nih.gov/pubmed/21698289
http://dx.doi.org/10.1371/journal.pone.0020215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115951/
https://www.ncbi.nlm.nih.gov/pubmed/21698289
http://dx.doi.org/10.1371/journal.pone.0020215

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