Therapeutic Potential and Challenges of Targeting Receptor Tyrosine Kinase ROR1 with Monoclonal Antibodies in B-Cell Malignancies

BACKGROUND: Based on its selective cell surface expression in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), receptor tyrosine kinase ROR1 has recently emerged as a promising target for therapeutic monoclonal antibodies (mAbs). To further assess the suitability of ROR1 for target...

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Detalles Bibliográficos
Autores principales: Yang, Jiahui, Baskar, Sivasubramanian, Kwong, Ka Yin, Kennedy, Michael G., Wiestner, Adrian, Rader, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115963/
https://www.ncbi.nlm.nih.gov/pubmed/21698301
http://dx.doi.org/10.1371/journal.pone.0021018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115963/
https://www.ncbi.nlm.nih.gov/pubmed/21698301
http://dx.doi.org/10.1371/journal.pone.0021018

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