Formalin Fixation at Low Temperature Better Preserves Nucleic Acid Integrity

Fixation with formalin, a widely adopted procedure to preserve tissue samples, leads to extensive degradation of nucleic acids and thereby compromises procedures like microarray-based gene expression profiling. We hypothesized that RNA fragmentation is caused by activation of RNAses during the inter...

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Detalles Bibliográficos
Autores principales: Bussolati, Gianni, Annaratone, Laura, Medico, Enzo, D'Armento, Giuseppe, Sapino, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115967/
https://www.ncbi.nlm.nih.gov/pubmed/21698245
http://dx.doi.org/10.1371/journal.pone.0021043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115967/
https://www.ncbi.nlm.nih.gov/pubmed/21698245
http://dx.doi.org/10.1371/journal.pone.0021043

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