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Formalin Fixation at Low Temperature Better Preserves Nucleic Acid Integrity
Fixation with formalin, a widely adopted procedure to preserve tissue samples, leads to extensive degradation of nucleic acids and thereby compromises procedures like microarray-based gene expression profiling. We hypothesized that RNA fragmentation is caused by activation of RNAses during the inter...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115967/ https://www.ncbi.nlm.nih.gov/pubmed/21698245 http://dx.doi.org/10.1371/journal.pone.0021043 |