Neonatal Astrocyte Damage Is Sufficient to Trigger Progressive Striatal Degeneration in a Rat Model of Glutaric Acidemia-I

BACKGROUND: We have investigated whether an acute metabolic damage to astrocytes during the neonatal period may critically disrupt subsequent brain development, leading to neurodevelopmental disorders. Astrocytes are vulnerable to glutaric acid (GA), a dicarboxylic acid that accumulates in millimola...

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Detalles Bibliográficos
Autores principales: Olivera-Bravo, Silvia, Fernández, Anabel, Sarlabós, María Noel, Rosillo, Juan Carlos, Casanova, Gabriela, Jiménez, Marcie, Barbeito, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115973/
https://www.ncbi.nlm.nih.gov/pubmed/21698251
http://dx.doi.org/10.1371/journal.pone.0020831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115973/
https://www.ncbi.nlm.nih.gov/pubmed/21698251
http://dx.doi.org/10.1371/journal.pone.0020831

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