Conformationally Constrained Histidines in the Design of Peptidomimetics: Strategies for the χ-Space Control

A successful design of peptidomimetics must come to terms with χ-space control. The incorporation of χ-space constrained amino acids into bioactive peptides renders the χ(1) and χ(2) torsional angles of pharmacophore amino acids critical for activity and selectivity as with other relevant structural...

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Detalles Bibliográficos
Autores principales: Stefanucci, Azzurra, Pinnen, Francesco, Feliciani, Federica, Cacciatore, Ivana, Lucente, Gino, Mollica, Adriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116161/
https://www.ncbi.nlm.nih.gov/pubmed/21686155
http://dx.doi.org/10.3390/ijms12052853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116161/
https://www.ncbi.nlm.nih.gov/pubmed/21686155
http://dx.doi.org/10.3390/ijms12052853

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