3D-QSAR Studies on a Series of Dihydroorotate Dehydrogenase Inhibitors: Analogues of the Active Metabolite of Leflunomide

The active metabolite of the novel immunosuppressive agent leflunomide has been shown to inhibit the enzyme dihydroorotate dehydrogenase (DHODH). This enzyme catalyzes the fourth step in de novo pyrimidine biosynthesis. Self-organizing molecular field analysis (SOMFA), a simple three-dimensional qua...

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Detalles Bibliográficos
Autores principales: Li, Shun-Lai, He, Mao-Yu, Du, Hong-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116169/
https://www.ncbi.nlm.nih.gov/pubmed/21686163
http://dx.doi.org/10.3390/ijms12052982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116169/
https://www.ncbi.nlm.nih.gov/pubmed/21686163
http://dx.doi.org/10.3390/ijms12052982

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