Knockdown of Akt Sensitizes Osteosarcoma Cells to Apoptosis Induced by Cisplatin Treatment

Akt plays an important role in the inhibition of apoptosis induced by chemotherapy and other stimuli. We therefore investigated if knockdown of Akt2 promoted drug-induced apoptosis in cultured osteosarcoma cells in vitro. SAOS-2 cells were transfected with Akt2 siRNA. The sensitivity of the transfor...

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Detalles Bibliográficos
Autores principales: Zhang, Guoyou, Li, Ming, Zhu, Xiaodong, Bai, Yushu, Yang, Changwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116170/
https://www.ncbi.nlm.nih.gov/pubmed/21686164
http://dx.doi.org/10.3390/ijms12052994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116170/
https://www.ncbi.nlm.nih.gov/pubmed/21686164
http://dx.doi.org/10.3390/ijms12052994

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