High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis

The African trypanosome Trypanosoma brucei, which persists within the bloodstream of the mammalian host, has evolved potent mechanisms for immune evasion. Specifically, antigenic variation of the variant-specific surface glycoprotein (VSG) and a highly active endocytosis and recycling of the surface...

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Detalles Bibliográficos
Autores principales: Stijlemans, Benoît, Caljon, Guy, Natesan, Senthil Kumar A., Saerens, Dirk, Conrath, Katja, Pérez-Morga, David, Skepper, Jeremy N., Nikolaou, Alexandros, Brys, Lea, Pays, Etienne, Magez, Stefan, Field, Mark C., De Baetselier, Patrick, Muyldermans, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116811/
https://www.ncbi.nlm.nih.gov/pubmed/21698216
http://dx.doi.org/10.1371/journal.ppat.1002072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116811/
https://www.ncbi.nlm.nih.gov/pubmed/21698216
http://dx.doi.org/10.1371/journal.ppat.1002072

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