Cargando…

High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis

The African trypanosome Trypanosoma brucei, which persists within the bloodstream of the mammalian host, has evolved potent mechanisms for immune evasion. Specifically, antigenic variation of the variant-specific surface glycoprotein (VSG) and a highly active endocytosis and recycling of the surface...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stijlemans, Benoît, Caljon, Guy, Natesan, Senthil Kumar A., Saerens, Dirk, Conrath, Katja, Pérez-Morga, David, Skepper, Jeremy N., Nikolaou, Alexandros, Brys, Lea, Pays, Etienne, Magez, Stefan, Field, Mark C., De Baetselier, Patrick, Muyldermans, Serge
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116811/ https://www.ncbi.nlm.nih.gov/pubmed/21698216 http://dx.doi.org/10.1371/journal.ppat.1002072

Ejemplares similares

Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies
por: Caljon, Guy, et al.
Publicado: (2012)

Correction: Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies
por: Caljon, Guy, et al.
Publicado: (2012)

The Trypanosomal Transferrin Receptor of Trypanosoma Brucei—A Review
por: Kariuki, Christopher K., et al.
Publicado: (2019)

Nanobodies As Tools to Understand, Diagnose, and Treat African Trypanosomiasis
por: Stijlemans, Benoit, et al.
Publicado: (2017)

Expression and extracellular release of a functional anti-trypanosome Nanobody(® )in Sodalis glossinidius, a bacterial symbiont of the tsetse fly
por: De Vooght, Linda, et al.
Publicado: (2012)

The Role of B-cells and IgM Antibodies in Parasitemia, Anemia, and VSG Switching in Trypanosoma brucei–Infected Mice
por: Magez, Stefan, et al.
Publicado: (2008)

Generation of a Nanobody Targeting the Paraflagellar Rod Protein of Trypanosomes
por: Obishakin, Emmanuel, et al.
Publicado: (2014)

Cohesin regulates VSG monoallelic expression in trypanosomes
por: Landeira, David, et al.
Publicado: (2009)

Differences between Trypanosoma brucei gambiense Groups 1 and 2 in Their Resistance to Killing by Trypanolytic Factor 1
por: Capewell, Paul, et al.
Publicado: (2011)

Iron Homeostasis and Trypanosoma brucei Associated Immunopathogenicity Development: A Battle/Quest for Iron
por: Stijlemans, Benoit, et al.
Publicado: (2015)

Neutrophils enhance early Trypanosoma brucei infection onset
por: Caljon, Guy, et al.
Publicado: (2018)

MIF Contributes to Trypanosoma brucei Associated Immunopathogenicity Development
por: Stijlemans, Benoît, et al.
Publicado: (2014)

The Role of MIF and IL-10 as Molecular Yin-Yang in the Modulation of the Host Immune Microenvironment During Infections: African Trypanosome Infections as a Paradigm
por: Stijlemans, Benoit, et al.
Publicado: (2022)

The VSG C-terminal domain is inaccessible to antibodies on live trypanosomes
por: Schwede, Angela, et al.
Publicado: (2011)

Targeting the tsetse-trypanosome interplay using genetically engineered Sodalis glossinidius
por: De Vooght, Linda, et al.
Publicado: (2022)

Immune Evasion Strategies of Trypanosoma brucei within the Mammalian Host: Progression to Pathogenicity
por: Stijlemans, Benoît, et al.
Publicado: (2016)

Masters of Disguise: Antigenic Variation and the VSG Coat in Trypanosoma brucei
por: Mugnier, Monica R., et al.
Publicado: (2016)

An Anti-proteome Nanobody Library Approach Yields a Specific Immunoassay for Trypanosoma congolense Diagnosis Targeting Glycosomal Aldolase
por: Odongo, Steven, et al.
Publicado: (2016)

Specific Uptake of Tumor Necrosis Factor-α Is Involved in Growth Control of Trypanosoma brucei
por: Magez, Stefan, et al.
Publicado: (1997)

Nuclear repositioning of the VSG promoter during developmental silencing in Trypanosoma brucei
por: Landeira, David, et al.
Publicado: (2007)

African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat
por: Pinger, Jason, et al.
Publicado: (2018)

An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes
por: Budzak, James, et al.
Publicado: (2022)

African Trypanosomes Undermine Humoral Responses and Vaccine Development: Link with Inflammatory Responses?
por: Stijlemans, Benoit, et al.
Publicado: (2017)

Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control
por: Glover, Lucy, et al.
Publicado: (2013)

How Does the VSG Coat of Bloodstream Form African Trypanosomes Interact with External Proteins?
por: Schwede, Angela, et al.
Publicado: (2015)

Histone deacetylases play distinct roles in telomeric VSG expression site silencing in African trypanosomes
por: Wang, Qiao-Ping, et al.
Publicado: (2010)

Life and times: synthesis, trafficking, and evolution of VSG
por: Manna, Paul T., et al.
Publicado: (2014)

Tsetse Salivary Gland Proteins 1 and 2 Are High Affinity Nucleic Acid Binding Proteins with Residual Nuclease Activity
por: Caljon, Guy, et al.
Publicado: (2012)

Hepatocyte-derived IL-10 plays a crucial role in attenuating pathogenicity during the chronic phase of T. congolense infection
por: Stijlemans, Benoit, et al.
Publicado: (2020)

Tsetse fly tolerance to T. brucei infection: transcriptome analysis of trypanosome-associated changes in the tsetse fly salivary gland
por: Matetovici, Irina, et al.
Publicado: (2016)

NLP is a novel transcription regulator involved in VSG expression site control in Trypanosoma brucei
por: Narayanan, Mani Shankar, et al.
Publicado: (2011)

Trypanosoma brucei gambiense Adaptation to Different Mammalian Sera Is Associated with VSG Expression Site Plasticity
por: Cordon-Obras, Carlos, et al.
Publicado: (2013)

Trypanosoma brucei Interaction with Host: Mechanism of VSG Release as Target for Drug Discovery for African Trypanosomiasis
por: Moreno, Cláudia Jassica Gonçalves, et al.
Publicado: (2019)

Trypanosoma brucei TIF2 and TRF Suppress VSG Switching Using Overlapping and Independent Mechanisms
por: Jehi, Sanaa E., et al.
Publicado: (2016)

VEX1 Influences mVSG Expression During the Transition to Mammalian Infectivity in Trypanosoma brucei
por: Tihon, Eliane, et al.
Publicado: (2022)

The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expression
por: Gaurav, Amit Kumar, et al.
Publicado: (2023)

Locus-specific control of DNA resection and suppression of subtelomeric VSG recombination by HAT3 in the African trypanosome
por: Glover, Lucy, et al.
Publicado: (2014)

The molecular size of the extra-membrane domain influences the diffusion of the GPI-anchored VSG on the trypanosome plasma membrane
por: Hartel, Andreas J. W., et al.
Publicado: (2015)

Pedal to the Metal: Nuclear Splicing Bodies Turbo-Charge VSG mRNA Production in African Trypanosomes
por: Budzak, James, et al.
Publicado: (2022)

Isolation and analysis of the genetic diversity of repertoires of VSG expression site containing telomeres from Trypanosoma brucei gambiense, T. b. brucei and T. equiperdum
por: Young, Rosanna, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_81j2v0pr86o0sst5ql18j75gl1