Induction of Noxa-Mediated Apoptosis by Modified Vaccinia Virus Ankara Depends on Viral Recognition by Cytosolic Helicases, Leading to IRF-3/IFN-β-Dependent Induction of Pro-Apoptotic Noxa

Viral infection is a stimulus for apoptosis, and in order to sustain viral replication many viruses are known to carry genes encoding apoptosis inhibitors. F1L, encoded by the orthopoxvirus modified vaccinia virus Ankara (MVA) has a Bcl-2-like structure. An MVA mutant lacking F1L (MVAΔF1L) induces a...

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Detalles Bibliográficos
Autores principales: Eitz Ferrer, Pedro, Potthoff, Stephanie, Kirschnek, Susanne, Gasteiger, Georg, Kastenmüller, Wolfgang, Ludwig, Holger, Paschen, Stefan A., Villunger, Andreas, Sutter, Gerd, Drexler, Ingo, Häcker, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116819/
https://www.ncbi.nlm.nih.gov/pubmed/21698224
http://dx.doi.org/10.1371/journal.ppat.1002083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116819/
https://www.ncbi.nlm.nih.gov/pubmed/21698224
http://dx.doi.org/10.1371/journal.ppat.1002083

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