Cargando…

ER Stress Induces Anabolic Resistance in Muscle Cells through PKB-Induced Blockade of mTORC1

BACKGROUND: Anabolic resistance is the inability to increase protein synthesis in response to an increase in amino acids following a meal. One potential mediator of anabolic resistance is endoplasmic reticulum (ER) stress. The purpose of the present study was to test whether ER stress impairs the re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deldicque, Louise, Bertrand, Luc, Patton, Amy, Francaux, Marc, Baar, Keith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116857/ https://www.ncbi.nlm.nih.gov/pubmed/21698202 http://dx.doi.org/10.1371/journal.pone.0020993

Ejemplares similares

Aging Reduces the Activation of the mTORC1 Pathway after Resistance Exercise and Protein Intake in Human Skeletal Muscle: Potential Role of REDD1 and Impaired Anabolic Sensitivity
por: Francaux, Marc, et al.
Publicado: (2016)

mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4
por: Castets, Perrine, et al.
Publicado: (2019)

Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation
por: Lee Hamilton, D., et al.
Publicado: (2014)

mTORC1 beyond anabolic metabolism: Regulation of cell death
por: Zhu, Jiajun, et al.
Publicado: (2022)

mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling
por: Bravo-Sagua, Roberto, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast‐immobilized mouse hindlimb
por: Shimkus, Kevin L., et al.
Publicado: (2018)

PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia
por: Howell, Kristy R., et al.
Publicado: (2017)

Ras-mediated activation of the TORC2–PKB pathway is critical for chemotaxis
por: Cai, Huaqing, et al.
Publicado: (2010)

Hippo Pathway and Skeletal Muscle Mass Regulation in Mammals: A Controversial Relationship
por: Gnimassou, Olouyomi, et al.
Publicado: (2017)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans
por: Smith, Hannah J., et al.
Publicado: (2023)

Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization
por: Baek, Mi-Ock, et al.
Publicado: (2018)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice
por: Ehinger, Yann, et al.
Publicado: (2021)

Cannabidiol Does Not Impact Acute Anabolic or Inflammatory Signaling in Skeletal Muscle In Vitro
por: Langer, Henning T., et al.
Publicado: (2022)

A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity
por: Khamsing, Dany, et al.
Publicado: (2021)

Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1
por: Du, Heng, et al.
Publicado: (2023)

ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway
por: Chen, Guohua, et al.
Publicado: (2020)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation
por: Alayev, A, et al.
Publicado: (2015)

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase
por: D’Hulst, Gommaar, et al.
Publicado: (2020)

The role of mTORC1 in the regulation of skeletal muscle mass
por: Bodine, Sue C
Publicado: (2022)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

Recommendations for Healthy Nutrition in Female Endurance Runners: An Update
por: Deldicque, Louise, et al.
Publicado: (2015)

Fifteen days of 3,200 m simulated hypoxia marginally regulates markers for protein synthesis and degradation in human skeletal muscle
por: D’Hulst, Gommaar, et al.
Publicado: (2016)

Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
por: McCabe, Matthew P, et al.
Publicado: (2020)

mTORC1 inhibition impairs activation of the unfolded protein response and induces cell death during ER stress in cardiomyocytes
por: Hofmann, Christoph, et al.
Publicado: (2023)

Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis
por: Fry, Christopher S, et al.
Publicado: (2011)

mTORC1 Mediates Lysine-Induced Satellite Cell Activation to Promote Skeletal Muscle Growth
por: Jin, Cheng-long, et al.
Publicado: (2019)

Myofibrillar protein synthesis rates are increased in chronically exercised skeletal muscle despite decreased anabolic signaling
por: Langer, Henning T., et al.
Publicado: (2022)

mTORC1 Regulates Flagellin-Induced Inflammatory Response in Macrophages
por: Bao, Wenlei, et al.
Publicado: (2015)

mTORC1 Signaling and Negative Lens-Induced Axial Elongation
por: Zhang, Ruiheng, et al.
Publicado: (2023)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

TGFβ-Induced Deptor Suppression Recruits mTORC1 and Not mTORC2 to Enhance Collagen I (α2) Gene Expression
por: Das, Falguni, et al.
Publicado: (2014)

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
por: Miao, Linqing, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_7ok3kbn2j8g9gjfnqot3c6mpd1