Mutation D816V Alters the Internal Structure and Dynamics of c-KIT Receptor Cytoplasmic Region: Implications for Dimerization and Activation Mechanisms

The type III receptor tyrosine kinase (RTK) KIT plays a crucial role in the transmission of cellular signals through phosphorylation events that are associated with a switching of the protein conformation between inactive and active states. D816V KIT mutation is associated with various pathologies i...

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Detalles Bibliográficos
Autores principales: Laine, Elodie, Chauvot de Beauchêne, Isaure, Perahia, David, Auclair, Christian, Tchertanov, Luba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116893/
https://www.ncbi.nlm.nih.gov/pubmed/21698178
http://dx.doi.org/10.1371/journal.pcbi.1002068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116893/
https://www.ncbi.nlm.nih.gov/pubmed/21698178
http://dx.doi.org/10.1371/journal.pcbi.1002068

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