Amino Acid Substitutions at the Major Insertion Loop of Candida albicans Sterol 14alpha-Demethylase Are Involved in Fluconazole Resistance

BACKGROUND: In the fungal pathogen Candida albicans, amino acid substitutions of 14alpha-demethylase (CaErg11p, CaCYP51) are associated with azole antifungals resistance. This is an area of research which is very dynamic, since the stakes concern the screening of new antifungals which circumvent res...

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Detalles Bibliográficos
Autores principales: Alvarez-Rueda, Nidia, Fleury, Audrey, Morio, Florent, Pagniez, Fabrice, Gastinel, Louis, Le Pape, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116904/
https://www.ncbi.nlm.nih.gov/pubmed/21698128
http://dx.doi.org/10.1371/journal.pone.0021239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116904/
https://www.ncbi.nlm.nih.gov/pubmed/21698128
http://dx.doi.org/10.1371/journal.pone.0021239

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