Multiple Regulatory Mechanisms to Inhibit Untimely Initiation of DNA Replication Are Important for Stable Genome Maintenance

Genomic instability is a hallmark of human cancer cells. To prevent genomic instability, chromosomal DNA is faithfully duplicated in every cell division cycle, and eukaryotic cells have complex regulatory mechanisms to achieve this goal. Here, we show that untimely activation of replication origins...

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Detalles Bibliográficos
Autores principales: Tanaka, Seiji, Araki, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116906/
https://www.ncbi.nlm.nih.gov/pubmed/21698130
http://dx.doi.org/10.1371/journal.pgen.1002136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116906/
https://www.ncbi.nlm.nih.gov/pubmed/21698130
http://dx.doi.org/10.1371/journal.pgen.1002136

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