Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells

In normal cells, telomeres shorten each time a cell divides ultimately resulting in cell senescence. t In contrast, cancer cells counteract the loss of telomeric DNA either by inducing the expression of telomerase or by activating the Alternative Lengthening of Telomeres (ALT) pathway. ALT cells are...

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Detalles Bibliográficos
Autores principales: Li, Baomin, Reddy, Sita, Comai, Lucio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117455/
https://www.ncbi.nlm.nih.gov/pubmed/21512205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117455/
https://www.ncbi.nlm.nih.gov/pubmed/21512205

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