Reversing the aging stromal phenotype prevents carcinoma initiation

The accumulation of senescent stromal cells in aging tissue changes the local microenvironment from normal to a state similar to chronic inflammation. This inflammatory microenvironment can stimulate the proliferation of epithelial cells containing DNA mutations which can ultimately lead to cancer....

Descripción completa

Detalles Bibliográficos
Autores principales: Lewis, Davina A., Travers, Jeffrey B., Machado, Christiane, Somani, Ally-Khan, Spandau, Dan F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117456/
https://www.ncbi.nlm.nih.gov/pubmed/21515933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117456/
https://www.ncbi.nlm.nih.gov/pubmed/21515933

Ejemplares similares