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Reversing the aging stromal phenotype prevents carcinoma initiation

The accumulation of senescent stromal cells in aging tissue changes the local microenvironment from normal to a state similar to chronic inflammation. This inflammatory microenvironment can stimulate the proliferation of epithelial cells containing DNA mutations which can ultimately lead to cancer....

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Detalles Bibliográficos
Autores principales:	Lewis, Davina A., Travers, Jeffrey B., Machado, Christiane, Somani, Ally-Khan, Spandau, Dan F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2011
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117456/ https://www.ncbi.nlm.nih.gov/pubmed/21515933

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