PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease

BACKGROUND: Huntington disease (HD) is an inherited neurodegenerative disease caused by an abnormal expansion of a CAG repeat in the huntingtin HTT (HD) gene. The primary genetic determinant of the age at onset (AO) is the length of the HTT CAG repeat; however, the remaining genetic contribution to...

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Detalles Bibliográficos
Autores principales: Taherzadeh-Fard, Elahe, Saft, Carsten, Akkad, Denis A, Wieczorek, Stefan, Haghikia, Aiden, Chan, Andrew, Epplen, Jörg T, Arning, Larissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117738/
https://www.ncbi.nlm.nih.gov/pubmed/21595933
http://dx.doi.org/10.1186/1750-1326-6-32

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117738/
https://www.ncbi.nlm.nih.gov/pubmed/21595933
http://dx.doi.org/10.1186/1750-1326-6-32

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