Mutagenesis of tyrosine and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivity

BACKGROUND: The gp41 component of the Human Immunodeficiency Virus (HIV) envelope glycoprotein (Env) contains a long cytoplasmic domain (CD) with multiple highly conserved tyrosine (Y) and dileucine (LL) motifs. Studies suggest that the motifs distal to major endocytosis motif (Y(712)HRL), located a...

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Detalles Bibliográficos
Autores principales: Bhakta, Sushma J, Shang, Liang, Prince, Jessica L, Claiborne, Daniel T, Hunter, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117779/
https://www.ncbi.nlm.nih.gov/pubmed/21569545
http://dx.doi.org/10.1186/1742-4690-8-37

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117779/
https://www.ncbi.nlm.nih.gov/pubmed/21569545
http://dx.doi.org/10.1186/1742-4690-8-37

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